Uncle Harry...Is That You? tells the story of Krista and Jim Jackson who have just received a letter from Krista's Aunt Matilda stating that she is planning an extended visit to help her deal with the loss of her beloved husband Harry. When she mentions, however, that is also bringing her niece and her overbearing and controlling sister Sophie, who won't let anyone watch TV, this proves to be too much for Jim.
With his two bumbling friends Ed and Ben, who like to come over to watch the Red Sox baseball games, he tries to make sure the visit is a short one. However, all their attempts to get the ladies to leave fails and, in desperation, they decide to impersonate Uncle Harry. What results is one the improbably and unpredictable hilarious ghost stories ever presented on stage.